Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel

Relatively low reactivity hinders using chlorodifluoromethane (ClCF(2)H) for general difluoromethylation with organic molecules, despite its availability as an inexpensive industrial chemical. To date, transformations of ClCF(2)H are very limited and most of them involve difluorocarbene intermediate...

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Detalles Bibliográficos
Autores principales: Xu, Chang, Guo, Wen-Hao, He, Xu, Guo, Yin-Long, Zhang, Xue-Ying, Zhang, Xingang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862906/
https://www.ncbi.nlm.nih.gov/pubmed/29563528
http://dx.doi.org/10.1038/s41467-018-03532-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862906/
https://www.ncbi.nlm.nih.gov/pubmed/29563528
http://dx.doi.org/10.1038/s41467-018-03532-1

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