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Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
Relatively low reactivity hinders using chlorodifluoromethane (ClCF(2)H) for general difluoromethylation with organic molecules, despite its availability as an inexpensive industrial chemical. To date, transformations of ClCF(2)H are very limited and most of them involve difluorocarbene intermediate...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862906/ https://www.ncbi.nlm.nih.gov/pubmed/29563528 http://dx.doi.org/10.1038/s41467-018-03532-1 |