Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is caused by mutation of PKD1 or PKD2, which encode polycystin 1 and 2, respectively. The polycystins localize to primary cilia and the functional loss of the polycystin complex leads to the formation and progressive growth of fluid-filled cysts i...

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Detalles Bibliográficos
Autores principales: Silva, Luciane M., Jacobs, Damon T., Allard, Bailey A., Fields, Timothy A., Sharma, Madhulika, Wallace, Darren P., Tran, Pamela V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862907/
https://www.ncbi.nlm.nih.gov/pubmed/29563577
http://dx.doi.org/10.1038/s41598-018-23341-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862907/
https://www.ncbi.nlm.nih.gov/pubmed/29563577
http://dx.doi.org/10.1038/s41598-018-23341-2

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