Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype

The hERG channel is a key player in repolarization of the cardiac action potential. Pharmacological blockade of hERG channels depletes the cardiac repolarization reserve, increasing the risk of cardiac arrhythmias. The promiscuous nature of drug interactions with hERG presents a therapeutic challeng...

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Detalles Bibliográficos
Autores principales: Thouta, Samrat, Lo, Garman, Grajauskas, Lukas, Claydon, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862968/
https://www.ncbi.nlm.nih.gov/pubmed/29563525
http://dx.doi.org/10.1038/s41598-018-23346-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862968/
https://www.ncbi.nlm.nih.gov/pubmed/29563525
http://dx.doi.org/10.1038/s41598-018-23346-x

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