Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis

Although toxoplasmosis is one of the most common parasitic infections worldwide, therapeutic options remain limited. Cathepsins, proteases that play key roles in the pathogenesis of toxoplasmosis and many other protozoan infections, are important potential therapeutic targets. Because both TgCPB and...

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Detalles Bibliográficos
Autores principales: Chaparro, Juan D., Cheng, Timmy, Tran, Uyen Phuong, Andrade, Rosa M., Brenner, Sara B. T., Hwang, Grace, Cohn, Shara, Hirata, Ken, McKerrow, James H., Reed, Sharon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863946/
https://www.ncbi.nlm.nih.gov/pubmed/29565998
http://dx.doi.org/10.1371/journal.pone.0193982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863946/
https://www.ncbi.nlm.nih.gov/pubmed/29565998
http://dx.doi.org/10.1371/journal.pone.0193982

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