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Molecular modeling, dynamics simulations, and binding efficiency of berberine derivatives: A new group of RAF inhibitors for cancer treatment

RAF kinases are a family of enzymes in the MAP kinase pathway that contribute to the development of different types of cancer. BRAF is the most important member of RAF kinases. BRAF mutations have been detected in 7% of all cancers and 66% of melanomas; as such, the FDA has approved a few BRAF inhib...

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Detalles Bibliográficos
Autores principales: Jabbarzadeh Kaboli, Parham, Ismail, Patimah, Ling, King-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863970/
https://www.ncbi.nlm.nih.gov/pubmed/29565994
http://dx.doi.org/10.1371/journal.pone.0193941