The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial

BACKGROUND: Cardiovascular disease is a major cause of morbidity and mortality in COPD patients. Systemic inflammation associated with COPD, is often hypothesised as a causal factor. p38 mitogen-activated protein kinases play a key role in the inflammatory pathogenesis of COPD and atherosclerosis. O...

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Detalles Bibliográficos
Autores principales: Fisk, Marie, Cheriyan, Joseph, Mohan, Divya, Forman, Julia, Mäki-Petäjä, Kaisa M., McEniery, Carmel M., Fuld, Jonathan, Rudd, James H. F., Hopkinson, Nicholas S., Lomas, David A., Cockcroft, John R., Tal-Singer, Ruth, Polkey, Michael I., Wilkinson, Ian B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863984/
https://www.ncbi.nlm.nih.gov/pubmed/29566026
http://dx.doi.org/10.1371/journal.pone.0194197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863984/
https://www.ncbi.nlm.nih.gov/pubmed/29566026
http://dx.doi.org/10.1371/journal.pone.0194197

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