Early MinION(™) nanopore single-molecule sequencing technology enables the characterization of hepatitis B virus genetic complexity in clinical samples

Until recently, the method of choice to characterize viral diversity consisted in cloning PCR amplicons of full-length viral genomes and Sanger-sequencing of multiple clones. However, this is extremely laborious, time-consuming, and low-throughput. Next generation short-read sequencing appears also...

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Detalles Bibliográficos
Autores principales: Sauvage, Virginie, Boizeau, Laure, Candotti, Daniel, Vandenbogaert, Mathias, Servant-Delmas, Annabelle, Caro, Valérie, Laperche, Syria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864009/
https://www.ncbi.nlm.nih.gov/pubmed/29566006
http://dx.doi.org/10.1371/journal.pone.0194366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864009/
https://www.ncbi.nlm.nih.gov/pubmed/29566006
http://dx.doi.org/10.1371/journal.pone.0194366

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