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Early MinION(™) nanopore single-molecule sequencing technology enables the characterization of hepatitis B virus genetic complexity in clinical samples
Until recently, the method of choice to characterize viral diversity consisted in cloning PCR amplicons of full-length viral genomes and Sanger-sequencing of multiple clones. However, this is extremely laborious, time-consuming, and low-throughput. Next generation short-read sequencing appears also...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864009/ https://www.ncbi.nlm.nih.gov/pubmed/29566006 http://dx.doi.org/10.1371/journal.pone.0194366 |