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Controlled branched-chain amino acids auxotrophy in Listeria monocytogenes allows isoleucine to serve as a host signal and virulence effector

Listeria monocytogenes (Lm) is a saprophyte and intracellular pathogen. Transition to the pathogenic state relies on sensing of host-derived metabolites, yet it remains unclear how these are recognized and how they mediate virulence gene regulation. We previously found that low availability of isole...

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Detalles Bibliográficos
Autores principales: Brenner, Moran, Lobel, Lior, Borovok, Ilya, Sigal, Nadejda, Herskovits, Anat A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864092/
https://www.ncbi.nlm.nih.gov/pubmed/29529043
http://dx.doi.org/10.1371/journal.pgen.1007283