Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation

Voriconazole (VRCZ) induces the development of UV-associated skin cancers. The mechanism underlying the VRCZ-induced carcinogenesis has been largely unknown. Here, we showed that VRCZ metabolites plus UVA generated reactive oxygen species and resultant DNA damage of the epidermis, but did not induce...

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Detalles Bibliográficos
Autores principales: Ikeya, Shigeki, Sakabe, Jun-ichi, Yamada, Takahiro, Naito, Takafumi, Tokura, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864729/
https://www.ncbi.nlm.nih.gov/pubmed/29568008
http://dx.doi.org/10.1038/s41598-018-23439-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864729/
https://www.ncbi.nlm.nih.gov/pubmed/29568008
http://dx.doi.org/10.1038/s41598-018-23439-7

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