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Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation

Voriconazole (VRCZ) induces the development of UV-associated skin cancers. The mechanism underlying the VRCZ-induced carcinogenesis has been largely unknown. Here, we showed that VRCZ metabolites plus UVA generated reactive oxygen species and resultant DNA damage of the epidermis, but did not induce...

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Detalles Bibliográficos
Autores principales:	Ikeya, Shigeki, Sakabe, Jun-ichi, Yamada, Takahiro, Naito, Takafumi, Tokura, Yoshiki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864729/ https://www.ncbi.nlm.nih.gov/pubmed/29568008 http://dx.doi.org/10.1038/s41598-018-23439-7

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