Cargando…

Taurine protects dopaminergic neurons in a mouse Parkinson’s disease model through inhibition of microglial M1 polarization

Microglia-mediated neuroinflammation is implicated in multiple neurodegenerative disorders, including Parkinson’s disease (PD). Hence, the modulatioein of sustained microglial activation may have therapeutic potential. This study is designed to test the neuroprotective efficacy of taurine, a major i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Che, Yuning, Hou, Liyan, Sun, Fuqiang, Zhang, Cong, Liu, Xiaofang, Piao, Fengyuan, Zhang, Dan, Li, Huihua, Wang, Qingshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864871/ https://www.ncbi.nlm.nih.gov/pubmed/29568078 http://dx.doi.org/10.1038/s41419-018-0468-2

Ejemplares similares

2,5-Hexanedione induces dopaminergic neurodegeneration through integrin α(M)β2/NADPH oxidase axis-mediated microglial activation
por: Zhang, Cong, et al.
Publicado: (2018)

Correction: 2,5-Hexanedione induces dopaminergic neurodegeneration through integrin α(M)β2/NADPH oxidase axis-mediated microglial activation
por: Zhang, Cong, et al.
Publicado: (2022)

Complement receptor 3 mediates NADPH oxidase activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway
por: Hou, Liyan, et al.
Publicado: (2017)

NADPH oxidase-derived H(2)O(2) mediates the regulatory effects of microglia on astrogliosis in experimental models of Parkinson's disease
por: Hou, Liyan, et al.
Publicado: (2017)

Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson’s Disease Mouse Model
por: Ruan, Zhengzheng, et al.
Publicado: (2022)

Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase
por: Jiang, Lulu, et al.
Publicado: (2016)

Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model
por: Zhang, Dongdong, et al.
Publicado: (2021)

Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model
por: Hou, Liyan, et al.
Publicado: (2019)

Parkinson's disease and dopaminergic neurons
Publicado: (2012)

Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation
por: Zhang, Ruiping, et al.
Publicado: (2011)

Protection effect of taurine on nitrosative stress in the mice brain with chronic exposure to arsenic
por: Ma, Ning, et al.
Publicado: (2010)

Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation
por: Liu, Jie, et al.
Publicado: (2015)

Licochalcone A Prevents the Loss of Dopaminergic Neurons by Inhibiting Microglial Activation in Lipopolysaccharide (LPS)-Induced Parkinson’s Disease Models
por: Huang, Bingxu, et al.
Publicado: (2017)

Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson’s disease
por: Cai, Hua-Ying, et al.
Publicado: (2021)

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway
por: Hou, Liyan, et al.
Publicado: (2017)

Parkinson’s Disease, the Dopaminergic Neuron and Gammahydroxybutyrate
por: Mamelak, Mortimer
Publicado: (2018)

Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson’s Disease Mouse Model
por: Jing, Lu, et al.
Publicado: (2021)

Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson’s Disease
por: Okuyama, Satoshi, et al.
Publicado: (2016)

Cytokine Profiling in Human iPSC-Derived Dopaminergic Neuronal and Microglial Cultures
por: Knappe, Evelyn, et al.
Publicado: (2023)

Vulnerability of Mesostriatal Dopaminergic Neurons in Parkinson's Disease
por: González-Hernández, Tomás, et al.
Publicado: (2010)

DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65
por: Lin, Zixuan, et al.
Publicado: (2021)

1α,25-Dihydroxyvitamin D(3) Protects Dopaminergic Neurons in Rodent Models of Parkinson's Disease through Inhibition of Microglial Activation
por: Kim, Joong-Seok, et al.
Publicado: (2006)

Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson’s Disease Models
por: Yang, Hanyu, et al.
Publicado: (2020)

Down-regulation of microglial activity attenuates axotomized nigral dopaminergic neuronal cell loss
por: Song, Dae-Yong, et al.
Publicado: (2013)

Hypertension and Diagnosis of Parkinson’s Disease: A Meta-Analysis of Cohort Studies
por: Hou, Liyan, et al.
Publicado: (2018)

Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid—Lesioned Parkinson’s Disease Models
por: He, Xuan, et al.
Publicado: (2019)

DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson’s disease
por: Kinugawa, Kiyoka, et al.
Publicado: (2013)

Roles of FGF20 in dopaminergic neurons and Parkinson's disease
por: Itoh, Nobuyuki, et al.
Publicado: (2013)

JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss
por: Wang, Qing, et al.
Publicado: (2018)

Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits
por: Wang, Tzu-Feng, et al.
Publicado: (2022)

Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation
por: Hou, Liyan, et al.
Publicado: (2023)

CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease
por: Zhang, Shi, et al.
Publicado: (2011)

Bone marrow mesenchymal stem cells attenuate 2,5-hexanedione-induced neuronal apoptosis through a NGF/AKT-dependent pathway
por: Wang, Qingshan, et al.
Publicado: (2016)

Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis
por: McNeill, Alisdair, et al.
Publicado: (2013)

Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson’s Disease
por: Song, Juhyun, et al.
Publicado: (2016)

Induced dopaminergic neurons: A new promise for Parkinson’s disease
por: Xu, Zhimin, et al.
Publicado: (2017)

Moxibustion Protects Dopaminergic Neurons in Parkinson's Disease through Antiferroptosis
por: Huang, Zifeng, et al.
Publicado: (2021)

Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease
por: Vijitruth, Rattanavijit, et al.
Publicado: (2006)

Olfactory Sensory Activity Modulates Microglial-Neuronal Interactions during Dopaminergic Cell Loss in the Olfactory Bulb
por: Grier, Bryce D., et al.
Publicado: (2016)

Taurine inhibits 2,5-hexanedione-induced oxidative stress and mitochondria-dependent apoptosis in PC12 cells
por: LI, Shuangyue, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_054tv57or6dd4qkhapcr5bru9v