In vivo depletion of serum IgG by an affibody molecule binding the neonatal Fc receptor

Lowering the total level of Immunoglobulin G (IgG) in circulation is a promising general treatment option for many autoimmune diseases driven by pathogenic autoantibodies. The half-life of IgG in circulation is unusually long as a consequence of its interaction with the neonatal Fc receptor (FcRn),...

Descripción completa

Detalles Bibliográficos
Autores principales: Seijsing, Johan, Yu, Shengze, Frejd, Fredrik Y, Höiden-Guthenberg, Ingmarie, Gräslund, Torbjörn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865129/
https://www.ncbi.nlm.nih.gov/pubmed/29572538
http://dx.doi.org/10.1038/s41598-018-23481-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865129/
https://www.ncbi.nlm.nih.gov/pubmed/29572538
http://dx.doi.org/10.1038/s41598-018-23481-5

Ejemplares similares