Cargando…

Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-dependent cellular cytotoxicity (ADCC), and releasing cytokines. Although growing evidence supports NK cell antiviral immunity in HIV-1 infection, further knowledge of their response is necessary. Her...

Descripción completa

Detalles Bibliográficos
Autores principales:	Costanzo, Margaret C., Kim, Dohoon, Creegan, Matthew, Lal, Kerri G., Ake, Julie A., Currier, Jeffrey R., Streeck, Hendrik, Robb, Merlin L., Michael, Nelson L., Bolton, Diane L., Steers, Nicholas J., Eller, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865158/ https://www.ncbi.nlm.nih.gov/pubmed/29572470 http://dx.doi.org/10.1038/s41467-018-03618-w

Ejemplares similares

Single-Cell Profiling of Latently SIV-Infected CD4(+) T Cells Directly Ex Vivo to Reveal Host Factors Supporting Reservoir Persistence
por: Tokarev, Andrey, et al.
Publicado: (2022)

Terminal Effector CD8 T Cells Defined by an IKZF2(+)IL-7R(−) Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity
por: Naluyima, Prossy, et al.
Publicado: (2019)

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection
por: Lal, Kerri G., et al.
Publicado: (2020)

Associations Between Antibody Fc-Mediated Effector Functions and Long-Term Sequelae in Ebola Virus Survivors
por: Paquin-Proulx, Dominic, et al.
Publicado: (2021)

P10-12. Altered NK cell phenotype and function in Ugandans with chronic HIV-1 infection
por: Eller, MA, et al.
Publicado: (2009)

Accessories to SIV Control: T Cell Vaccination Shows Potential
por: Robb, Merlin L., et al.
Publicado: (2017)

Preferential and persistent impact of acute HIV-1 infection on CD4(+) iNKT cells in colonic mucosa
por: Paquin-Proulx, Dominic, et al.
Publicado: (2021)

Defining epitope coverage requirements for T cell-based HIV vaccines: Theoretical considerations and practical applications
por: Currier, Jeffrey R, et al.
Publicado: (2011)

Dissecting drivers of immune activation in chronic HIV-1 infection
por: Streeck, Hendrik, et al.
Publicado: (2022)

Preparing for future European efficacy trials of interventions to prevent HIV and other sexually transmitted infections: Lessons on willingness to participate and barriers to participation from ten German clinics serving behaviorally vulnerable men who have sex with men
por: Esber, Allahna L., et al.
Publicado: (2023)

High hepatitis B vaccination coverage among a cohort of predominantly men who have sex with men in Germany
por: Esber, Allahna L., et al.
Publicado: (2023)

Signatures of Human NK Cell Development and Terminal Differentiation
por: Luetke-Eversloh, Merlin, et al.
Publicado: (2013)

Longitudinal Analysis of Peripheral and Colonic CD161(+) CD4(+) T Cell Dysfunction in Acute HIV-1 Infection and Effects of Early Treatment Initiation
por: Lal, Kerri G., et al.
Publicado: (2020)

Assessing Prevalence and Transmission Rates of Malaria through Simultaneous Profiling of Antibody Responses against Plasmodium and Anopheles Antigens
por: Chaudhury, Sidhartha, et al.
Publicado: (2022)

Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection
por: Sharma, Vishakha, et al.
Publicado: (2021)

High-Throughput High-Resolution Class I HLA Genotyping in East Africa
por: Koehler, Rebecca N., et al.
Publicado: (2010)

A Double-Blind Randomized Phase I Clinical Trial Targeting ALVAC-HIV Vaccine to Human Dendritic Cells
por: Eller, Michael A., et al.
Publicado: (2011)

The Role of Natural Killer (NK) Cells and NK Cell Receptor Polymorphisms in the Assessment of HIV-1 Neutralization
por: Brown, Bruce K., et al.
Publicado: (2012)

Missverständnis Herdenimmunität
por: Streeck, Hendrik, et al.
Publicado: (2021)

Relatively Low HIV Infection Rates in Rural Uganda, but with High Potential for a Rise: A Cohort Study in Kayunga District, Uganda
por: Guwatudde, David, et al.
Publicado: (2009)

Preferential Infection of α4β7(+) Memory CD4(+) T Cells During Early Acute Human Immunodeficiency Virus Type 1 Infection
por: Tokarev, Andrey, et al.
Publicado: (2020)

HIV-1 Envelope Resistance to Proteasomal Cleavage: Implications for Vaccine Induced Immune Responses
por: Steers, Nicholas J., et al.
Publicado: (2012)

Innate and Adaptive Immune Responses Both Contribute to Pathological CD4 T Cell Activation in HIV-1 Infected Ugandans
por: Eller, Michael A., et al.
Publicado: (2011)

The breadth of HIV-1 neutralizing antibodies depends on the conservation of key sites in their epitopes
por: Bai, Hongjun, et al.
Publicado: (2019)

Impaired natural killer cell responses are associated with loss of the highly activated NKG2A(+)CD57(+)CD56(dim) subset in HIV-1 subtype D infection in Uganda
por: Naluyima, Prossy, et al.
Publicado: (2014)

Sex and Urbanicity Contribute to Variation in Lymphocyte Distribution across Ugandan Populations
por: Naluyima, Prossy, et al.
Publicado: (2016)

Factors associated with testing for HIV and hepatitis C among behaviorally vulnerable men in Germany: a cross-sectional analysis upon enrollment into an observational cohort
por: Crowell, Trevor A., et al.
Publicado: (2021)

Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge
por: Om, Kier, et al.
Publicado: (2020)

Reference Intervals in Healthy Adult Ugandan Blood Donors and Their Impact on Conducting International Vaccine Trials
por: Eller, Leigh Anne, et al.
Publicado: (2008)

B Cell Depletion in HIV-1 Subtype A Infected Ugandan Adults: Relationship to CD4 T Cell Count, Viral Load and Humoral Immune Responses
por: Oballah, Peter, et al.
Publicado: (2011)

A de novo approach to inferring within-host fitness effects during untreated HIV-1 infection
por: Illingworth, Christopher J. R., et al.
Publicado: (2020)

A mutational signature in gastric cancer suggests therapeutic strategies
por: Alexandrov, Ludmil B., et al.
Publicado: (2015)

Identification of Acute HIV-1 Infection by Hologic Aptima HIV-1 RNA Qualitative Assay
por: Manak, Mark M., et al.
Publicado: (2017)

NK and T Cell Immunological Signatures in Hospitalized Patients with COVID-19
por: Bergantini, Laura, et al.
Publicado: (2021)

ALVAC-HIV and AIDSVAX B/E vaccination induce improved immune responses compared with AIDSVAX B/E vaccination alone
por: Costanzo, Margaret C., et al.
Publicado: (2023)

Viral kinetics in untreated versus treated acute HIV infection in prospective cohort studies in Thailand
por: Ananworanich, Jintanat, et al.
Publicado: (2017)

Heightened metabolic responses in NK cells from patients with neuroblastoma suggests increased potential for immunotherapy
por: Slattery, Karen, et al.
Publicado: (2022)

Humoral Response to the HIV-1 Envelope V2 Region in a Thai Early Acute Infection Cohort
por: Trinh, Hung V., et al.
Publicado: (2019)

Unique metabolism and protein expression signature in human decidual NK cells
por: Wang, Ping, et al.
Publicado: (2023)

Review of tipranavir in the treatment of drug-resistant HIV
por: Streeck, Hendrik, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_n0itn5l5emm1i8gu05dnhqdocs