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MultiBacMam Bimolecular Fluorescence Complementation (BiFC) tool-kit identifies new small-molecule inhibitors of the CDK5-p25 protein-protein interaction (PPI)
Protein-protein interactions (PPIs) are at the core of virtually all biological processes in cells. Consequently, targeting PPIs is emerging at the forefront of drug discovery. Cellular assays which closely recapitulate native conditions in vivo are instrumental to understand how small molecule drug...
Autores principales: | Bellón-Echeverría, Itxaso, Carralot, Jean-Philippe, Del Rosario, Andrea Araujo, Kueng, Stephanie, Mauser, Harald, Schmid, Georg, Thoma, Ralf, Berger, Imre |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865166/ https://www.ncbi.nlm.nih.gov/pubmed/29572554 http://dx.doi.org/10.1038/s41598-018-23516-x |
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