Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

Lactate exchange between glycolytic and oxidative cancer cells is proposed to optimize tumor growth. Blocking lactate uptake through monocarboxylate transporter 1 (MCT1) represents an attractive therapeutic strategy but may stimulate glucose consumption by oxidative cancer cells. We report here that...

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Detalles Bibliográficos
Autores principales: Corbet, Cyril, Bastien, Estelle, Draoui, Nihed, Doix, Bastien, Mignion, Lionel, Jordan, Bénédicte F., Marchand, Arnaud, Vanherck, Jean-Christophe, Chaltin, Patrick, Schakman, Olivier, Becker, Holger M., Riant, Olivier, Feron, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865202/
https://www.ncbi.nlm.nih.gov/pubmed/29572438
http://dx.doi.org/10.1038/s41467-018-03525-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865202/
https://www.ncbi.nlm.nih.gov/pubmed/29572438
http://dx.doi.org/10.1038/s41467-018-03525-0

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