Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters

Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated. This study aims to explore the role of nuclea...

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Detalles Bibliográficos
Autores principales: Hou, Zhenyan, Chen, Lei, Fang, Pingfei, Cai, Hualin, Tang, Huaibo, Peng, Yongbo, Deng, Yang, Cao, Lingjuan, Li, Huande, Zhang, Bikui, Yan, Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865274/
https://www.ncbi.nlm.nih.gov/pubmed/29615906
http://dx.doi.org/10.3389/fphar.2018.00226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865274/
https://www.ncbi.nlm.nih.gov/pubmed/29615906
http://dx.doi.org/10.3389/fphar.2018.00226

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