Effects of the Phosphodiesterase-5 (PDE-5) Inhibitors, Avanafil and Zaprinast, on Bone Remodeling and Oxidative Damage in a Rat Model of Glucocorticoid-Induced Osteoporosis

BACKGROUND: The aim of this study was to evaluate the effects of the phosphodiesterase-5 (PDE-5) inhibitors, zaprinast and avanafil, on NO signalling pathway, bone mineral density (BMD), epiphyseal bone width, bone marrow angiogenesis, and parameters of oxidative stress in a rat model of glucocortic...

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Detalles Bibliográficos
Autores principales: Huyut, Zübeyir, Bakan, Nuri, Yıldırım, Serkan, Alp, Hamit Hakan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Animal Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865409/
https://www.ncbi.nlm.nih.gov/pubmed/29557941
http://dx.doi.org/10.12659/MSMBR.908504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865409/
https://www.ncbi.nlm.nih.gov/pubmed/29557941
http://dx.doi.org/10.12659/MSMBR.908504

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