Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis

OBJECTIVE: Amyotrophic lateral sclerosis (ALS) clinical trials based on single end points only partially capture the full treatment effect when both function and mortality are affected, and may falsely dismiss efficacious drugs as futile. We aimed to investigate the statistical properties of several...

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Detalles Bibliográficos
Autores principales: van Eijk, Ruben PA, Eijkemans, Marinus JC, Rizopoulos, Dimitris, van den Berg, Leonard H, Nikolakopoulos, Stavros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865572/
https://www.ncbi.nlm.nih.gov/pubmed/29593436
http://dx.doi.org/10.2147/CLEP.S153196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865572/
https://www.ncbi.nlm.nih.gov/pubmed/29593436
http://dx.doi.org/10.2147/CLEP.S153196

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