The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability

INTRODUCTION: Toltrazuril (Tol) is used to prevent and combat coccidiosis. However, its low aqueous solubility and poor oral bioavailability limit clinical application. METHODS: To overcome the shortcomings, toltrazuril–hydroxypropyl–β-cyclodextrin inclusion complex (Tol-HP-β-CD) was prepared and ch...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Liu, Mengxi, Lu, Chaocheng, Ren, Dandan, Fan, Guoqing, Liu, Chang, Liu, Mengjiao, Shu, Gang, Peng, Guangneng, Yuan, Zhixiang, Zhong, Zhijun, Zhang, Wei, Fu, Hualin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865576/
https://www.ncbi.nlm.nih.gov/pubmed/29593381
http://dx.doi.org/10.2147/DDDT.S157611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865576/
https://www.ncbi.nlm.nih.gov/pubmed/29593381
http://dx.doi.org/10.2147/DDDT.S157611

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