Cargando…

RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer

Hippo pathway target, YAP has emerged as an important player in solid tumor progression. Here, we identify RUNX1 and RUNX3 as novel negative regulators of oncogenic function of YAP in the context of breast cancer. RUNX proteins are one of the first transcription factors identified to interact with Y...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kulkarni, Madhura, Tan, Tuan Zea, Syed Sulaiman, Nurfarhanah Bte, Lamar, John M., Bansal, Prashali, Cui, Jianzhou, Qiao, Yiting, Ito, Yoshiaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865662/ https://www.ncbi.nlm.nih.gov/pubmed/29581836 http://dx.doi.org/10.18632/oncotarget.24419

Ejemplares similares

The Multiple Interactions of RUNX with the Hippo–YAP Pathway
por: Chuang, Linda Shyue Huey, et al.
Publicado: (2021)

RUNX3 in Stem Cell and Cancer Biology
por: Chuang, Linda Shyue Huey, et al.
Publicado: (2023)

RUNX3 is expressed in the epithelium of the gastrointestinal tract
por: Ito, Yoshiaki
Publicado: (2012)

Runx transcription factors in neuronal development
por: Inoue, Ken-ichi, et al.
Publicado: (2008)

RUNX1, a new regulator of EMT in breast cancer
por: Khawaled, Saleh, et al.
Publicado: (2017)

Functional relationship between p53 and RUNX proteins
por: Bae, Suk-Chul, et al.
Publicado: (2018)

RUNX3 loss turns on the dark side of TGF-beta signaling
por: Krishnan, Vaidehi, et al.
Publicado: (2017)

RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner
por: Abdallah, Mohamed Gaber, et al.
Publicado: (2021)

The transcription factor RUNX2 fuels YAP1 signaling and gastric cancer tumorigenesis
por: Guo, Zhengjun, et al.
Publicado: (2021)

Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb(−/−)Runx2(+/−) Murine Incisors
por: Saito, Kazuyuki, et al.
Publicado: (2018)

Volunteer unrelated donor cell‐derived acute myeloid leukemia with RUNX1‐RUNX1T1
por: Hagiwara, Shinya, et al.
Publicado: (2021)

Addiction to RUNX in lymphoma
por: Neil, James C., et al.
Publicado: (2016)

RUNX2 and Cancer
por: Lin, Tsung-Chieh
Publicado: (2023)

Thrombospondin-1 Is a Putative Target Gene of Runx2 and Runx3
por: Shi, Xiuming, et al.
Publicado: (2013)

The RUNX1/RUNX1T1 network: translating insights into therapeutic options
por: Swart, Laura E., et al.
Publicado: (2021)

Prognostic Impacts of D816V KIT Mutation and Peri-Transplant RUNX1–RUNX1T1 MRD Monitoring on Acute Myeloid Leukemia with RUNX1–RUNX1T1
por: Cho, Byung-Sik, et al.
Publicado: (2021)

Transcription Factors Runx1 and Runx3 Suppress Keratin Expression in Undifferentiated Keratinocytes
por: Ogawa, Eisaku, et al.
Publicado: (2022)

RUNX1 and breast cancer
por: Mercado-Matos, Jose, et al.
Publicado: (2017)

Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity
por: Aho, Teija LT, et al.
Publicado: (2006)

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers
por: Illendula, Anuradha, et al.
Publicado: (2016)

Unique N-terminal sequences in two Runx1 isoforms are dispensable for Runx1 function
por: Nieke, Sebastian, et al.
Publicado: (2017)

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
por: Grinev, Vasily V., et al.
Publicado: (2021)

Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells
por: Omatsu, Yoshiki, et al.
Publicado: (2022)

p53 Deficiency-Dependent Oncogenicity of Runx3
por: Ito, Kosei, et al.
Publicado: (2023)

Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts
por: Qin, Xin, et al.
Publicado: (2020)

Structural Mad-ness
por: LeBrasseur, Nicole
Publicado: (2002)

Elizabeth Ness Ross
Publicado: (1915)

Wm. F. Ness
Publicado: (1912)

Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia
por: Hornung, Roman, et al.
Publicado: (2018)

Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells
por: Ju, Xiaoli, et al.
Publicado: (2014)

Ihh and Runx2/Runx3 Signaling Interact to Coordinate Early Chondrogenesis: A Mouse Model
por: Kim, Eun-Jung, et al.
Publicado: (2013)

Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement
por: Tokunaga, Kenji, et al.
Publicado: (2017)

CircRUNX2 through has‐miR‐203 regulates RUNX2 to prevent osteoporosis
por: Yin, Qudong, et al.
Publicado: (2018)

Elucidation of Novel Therapeutic Targets for Acute Myeloid Leukemias with RUNX1-RUNX1T1 Fusion
por: Yun, Jae Won, et al.
Publicado: (2019)

RUNX inhibitor suppresses graft‐versus‐host disease through targeting RUNX‐NFATC2 axis
por: Kubota, Hirohito, et al.
Publicado: (2021)

Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development
por: Nagata, Kosei, et al.
Publicado: (2022)

Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia
por: Klco, Jeffery, et al.
Publicado: (2023)

Hemophagocytic Lymphohistiocytosis in RUNX1::RUNX1T1 Positive AML with Blast Count Below 20%
por: Huang, Xingqin, et al.
Publicado: (2023)

RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer
por: Li, Qingyuan, et al.
Publicado: (2019)

The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy
por: Homan, Claire C., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_op92e7tpdi9hmg48pkcv4s38gh