Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog

The Sonic Hedgehog (Shh) signaling pathway has been implicated in the development and tumor progression of a number of human cancers. Using synthetic peptide mimics to mount an immune response, we generated a mouse mAb to the carboxy (C)-terminus of the Shh protein and characterized its preclinical...

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Detalles Bibliográficos
Autores principales: Tolani, Bhairavi, Hoang, Ngoc T., Acevedo, Luis A., Giroux Leprieur, Etienne, Li, Hui, He, Biao, Jablons, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865672/
https://www.ncbi.nlm.nih.gov/pubmed/29581846
http://dx.doi.org/10.18632/oncotarget.24510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865672/
https://www.ncbi.nlm.nih.gov/pubmed/29581846
http://dx.doi.org/10.18632/oncotarget.24510

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