The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK

The proto-oncogene MYC can trigger the unfolded protein response (UPR). The double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK), one of three primary branches of the UPR, is a key regulator of autophagy, promoting tumorigenesis. Upon activation of PERK, there is an...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Huang, Siqi, Tian, Ruicheng, Chen, Jing, Gao, Hongxiang, Xie, Chenjie, Shan, Yuhua, Zhang, Zhen, Gu, Song, Xu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865679/
https://www.ncbi.nlm.nih.gov/pubmed/29581853
http://dx.doi.org/10.18632/oncotarget.24214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865679/
https://www.ncbi.nlm.nih.gov/pubmed/29581853
http://dx.doi.org/10.18632/oncotarget.24214

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