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The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK

The proto-oncogene MYC can trigger the unfolded protein response (UPR). The double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK), one of three primary branches of the UPR, is a key regulator of autophagy, promoting tumorigenesis. Upon activation of PERK, there is an...

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Detalles Bibliográficos
Autores principales:	Wang, Jing, Huang, Siqi, Tian, Ruicheng, Chen, Jing, Gao, Hongxiang, Xie, Chenjie, Shan, Yuhua, Zhang, Zhen, Gu, Song, Xu, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865679/ https://www.ncbi.nlm.nih.gov/pubmed/29581853 http://dx.doi.org/10.18632/oncotarget.24214

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