The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models

Cisplatin is one of the most commonly used chemotherapeutic drugs; however, toxicity and tumor resistance limit its use. Studies using murine models and human subjects have shown that the time of day of cisplatin treatment influences renal and blood toxicities. We hypothesized that the mechanisms re...

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Detalles Bibliográficos
Autores principales: Dakup, Panshak P., Porter, Kenneth I., Little, Alexander A., Gajula, Rajendra P., Zhang, Hui, Skornyakov, Elena, Kemp, Michael G., Van Dongen, Hans P.A, Gaddameedhi, Shobhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865687/
https://www.ncbi.nlm.nih.gov/pubmed/29581861
http://dx.doi.org/10.18632/oncotarget.24539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865687/
https://www.ncbi.nlm.nih.gov/pubmed/29581861
http://dx.doi.org/10.18632/oncotarget.24539

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