Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma

The incidence of cutaneous squamous cell carcinoma (cSCC) is rising. Whilst the majority are cured surgically, aggressive metastatic cSCC carry a poor prognosis. Inactivating mutations in transforming growth factor beta (TGF-β) receptors have been identified amongst genetic drivers of sporadic tumou...

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Detalles Bibliográficos
Autores principales: Rose, Aidan M., Spender, Lindsay C., Stephen, Christopher, Mitchell, Alastair, Rickaby, William, Bray, Susan, Evans, Alan T., Dayal, Jasbani, Purdie, Karin J., Harwood, Catherine A., Proby, Charlotte M., Leigh, Irene M., Coates, Philip J., Inman, Gareth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865689/
https://www.ncbi.nlm.nih.gov/pubmed/29581863
http://dx.doi.org/10.18632/oncotarget.24545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865689/
https://www.ncbi.nlm.nih.gov/pubmed/29581863
http://dx.doi.org/10.18632/oncotarget.24545

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