Dexmedetomidine impairs P-glycoprotein-mediated efflux function in L02 cells via the adenosine 5′-monophosphate-activated protein kinase/nuclear factor-κB pathway

Dexmedetomidine (DEX) a type of the anaesthetic that has been widely used in anaesthesia and intensive care. However, whether DEX affects the pharmacokinetics of drugs remains elusive. As hepatic P-glycoprotein (P-gp) serves a critical role in the disposition of drugs, the present study aimed to add...

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Detalles Bibliográficos
Autores principales: He, Guo-Rong, Lin, Xiao-Kun, Wang, Yong-Biao, Chen, Cong-De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865967/
https://www.ncbi.nlm.nih.gov/pubmed/29393492
http://dx.doi.org/10.3892/mmr.2018.8549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865967/
https://www.ncbi.nlm.nih.gov/pubmed/29393492
http://dx.doi.org/10.3892/mmr.2018.8549

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