Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P(3) Production and Akt Activation

In obese adipose tissue, Toll-like receptor signaling in macrophages leads to insulin resistance in adipocytes. Similarly, Toll signaling in the Drosophila larval fat body blocks insulin-dependent growth and nutrient storage. We find that Toll acts cell autonomously to block growth but not PI(3,4,5)...

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Detalles Bibliográficos
Autores principales: Roth, Stephen W., Bitterman, Moshe D., Birnbaum, Morris J., Bland, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866056/
https://www.ncbi.nlm.nih.gov/pubmed/29514084
http://dx.doi.org/10.1016/j.celrep.2018.02.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866056/
https://www.ncbi.nlm.nih.gov/pubmed/29514084
http://dx.doi.org/10.1016/j.celrep.2018.02.033

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