Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition

Owing to the prevalence of tumor-associated macrophages (TAMs) in cancer and their unique influence upon disease progression and malignancy, macrophage-targeted interventions have attracted notable attention in cancer immunotherapy. However, tractable targets to reduce TAM activities remain very few...

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Detalles Bibliográficos
Autores principales: Giurisato, Emanuele, Xu, Qiuping, Lonardi, Silvia, Telfer, Brian, Russo, Ilaria, Pearson, Adam, Finegan, Katherine G., Wang, Wenbin, Wang, Jinhua, Gray, Nathanael S., Vermi, William, Xia, Zhengui, Tournier, Cathy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866536/
https://www.ncbi.nlm.nih.gov/pubmed/29507229
http://dx.doi.org/10.1073/pnas.1707929115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866536/
https://www.ncbi.nlm.nih.gov/pubmed/29507229
http://dx.doi.org/10.1073/pnas.1707929115

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