BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

Aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils in islets of Langerhans is associated with type 2 diabetes, and formation of toxic IAPP species is believed to contribute to the loss of insulin-producing beta cells. The BRICHOS domain of integral membrane protein 2B (Bri2), a tra...

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Detalles Bibliográficos
Autores principales: Oskarsson, Marie E., Hermansson, Erik, Wang, Ye, Welsh, Nils, Presto, Jenny, Johansson, Jan, Westermark, Gunilla T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866560/
https://www.ncbi.nlm.nih.gov/pubmed/29507232
http://dx.doi.org/10.1073/pnas.1715951115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866560/
https://www.ncbi.nlm.nih.gov/pubmed/29507232
http://dx.doi.org/10.1073/pnas.1715951115

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