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Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine

Monoterpenoid indole alkaloids (MIAs) possess a diversity of alkaloid skeletons whose biosynthesis is poorly understood. A bioinformatic search of candidate genes, combined with their virus-induced gene silencing, targeted MIA profiling and in vitro/in vivo pathway reconstitution identified and func...

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Detalles Bibliográficos
Autores principales: Qu, Yang, Easson, Michael E. A. M., Simionescu, Razvan, Hajicek, Josef, Thamm, Antje M. K., Salim, Vonny, De Luca, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866588/
https://www.ncbi.nlm.nih.gov/pubmed/29511102
http://dx.doi.org/10.1073/pnas.1719979115