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Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine
Monoterpenoid indole alkaloids (MIAs) possess a diversity of alkaloid skeletons whose biosynthesis is poorly understood. A bioinformatic search of candidate genes, combined with their virus-induced gene silencing, targeted MIA profiling and in vitro/in vivo pathway reconstitution identified and func...
Autores principales: | Qu, Yang, Easson, Michael E. A. M., Simionescu, Razvan, Hajicek, Josef, Thamm, Antje M. K., Salim, Vonny, De Luca, Vincenzo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866588/ https://www.ncbi.nlm.nih.gov/pubmed/29511102 http://dx.doi.org/10.1073/pnas.1719979115 |
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