A lanthipeptide library used to identify a protein–protein interaction inhibitor

We describe the production and screening of a genetically encoded library of 10(6) lanthipeptides in Escherichia coli using the substrate-tolerant lanthipeptide synthetase ProcM. This plasmidencoded library was combined with a bacterial reverse two-hybrid system for the interaction of the HIV p6 pro...

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Detalles Bibliográficos
Autores principales: Yang, Xiao, Lennard, Katherine R., He, Chang, Walker, Mark C., Ball, Andrew T., Doigneaux, Cyrielle, Tavassoli, Ali, van der Donk, Wilfred A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866752/
https://www.ncbi.nlm.nih.gov/pubmed/29507389
http://dx.doi.org/10.1038/s41589-018-0008-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866752/
https://www.ncbi.nlm.nih.gov/pubmed/29507389
http://dx.doi.org/10.1038/s41589-018-0008-5

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