Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity

Hexabromocyclododecane (HBCD) is a brominated flame retardant (BFR) that accumulates in humans and affects the nervous system. To elucidate the mechanisms of HBCD neurotoxicity, we used transcriptomic profiling in brains of female mice exposed through their diet to HBCD (199 mg/kg body weight per da...

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Detalles Bibliográficos
Autores principales: Reffatto, V., Rasinger, J. D., Carroll, T. S., Ganay, T., Lundebye, A.-K., Sekler, I., Hershfinkel, M., Hogstrand, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866835/
https://www.ncbi.nlm.nih.gov/pubmed/29177809
http://dx.doi.org/10.1007/s00204-017-2119-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866835/
https://www.ncbi.nlm.nih.gov/pubmed/29177809
http://dx.doi.org/10.1007/s00204-017-2119-2

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