Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data

Physiologically based kinetic (PBK) modelling-based reverse dosimetry is a promising tool for the prediction of in vivo developmental toxicity using in vitro concentration–response data. In the present study, the potential of this approach to predict the dose-dependent increase of uterus weight in r...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Mengying, van Ravenzwaay, Bennard, Fabian, Eric, Rietjens, Ivonne M. C. M., Louisse, Jochem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866837/
https://www.ncbi.nlm.nih.gov/pubmed/29234833
http://dx.doi.org/10.1007/s00204-017-2140-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866837/
https://www.ncbi.nlm.nih.gov/pubmed/29234833
http://dx.doi.org/10.1007/s00204-017-2140-5

Ejemplares similares