The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes

Tamoxifen, a standard therapy for breast cancer, is metabolized to compounds with anti-estrogenic as well as estrogen-like action at the estrogen receptor. Little is known about the formation of estrogen-like metabolites and their biological impact. Thus, we characterized the estrogen-like metabolit...

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Detalles Bibliográficos
Autores principales: Johänning, Janina, Kröner, Patrick, Thomas, Maria, Zanger, Ulrich M., Nörenberg, Astrid, Eichelbaum, Michel, Schwab, Matthias, Brauch, Hiltrud, Schroth, Werner, Mürdter, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866846/
https://www.ncbi.nlm.nih.gov/pubmed/29285606
http://dx.doi.org/10.1007/s00204-017-2147-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866846/
https://www.ncbi.nlm.nih.gov/pubmed/29285606
http://dx.doi.org/10.1007/s00204-017-2147-y

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