Translational Development of Microbiome‐Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates

Understanding the pharmacology of microbiome‐based therapeutics is required to support the development of new medicines. Strains of E. coli Nissle (EcN) were genetically modified and administered to cynomolgus monkeys at doses of 1 × 10(9) and 1 × 10(12) colony‐forming units (CFU)/day for 28 days. A...

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Detalles Bibliográficos
Autores principales: Kurtz, Caroline, Denney, William S., Blankstein, Larry, Guilmain, Sarah E., Machinani, Suman, Kotula, Jonathan, Saha, Saurabh, Miller, Paul, Brennan, Aoife M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866967/
https://www.ncbi.nlm.nih.gov/pubmed/29194983
http://dx.doi.org/10.1111/cts.12528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866967/
https://www.ncbi.nlm.nih.gov/pubmed/29194983
http://dx.doi.org/10.1111/cts.12528

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