Transcriptome analysis reveals TMPRSS6 isoforms with distinct functionalities

TMPRSS6 (matriptase‐2) is a type II transmembrane serine protease involved in iron homoeostasis. At the cell surface of hepatocytes, TMPRSS6 cleaves haemojuvelin (HJV) and regulates the BMP/SMAD signalling pathway leading to production of hepcidin, a key regulator of iron absorption. Although four T...

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Detalles Bibliográficos
Autores principales: Dion, Sébastien P., Béliveau, François, Désilets, Antoine, Ghinet, Mariana Gabriela, Leduc, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867103/
https://www.ncbi.nlm.nih.gov/pubmed/29441715
http://dx.doi.org/10.1111/jcmm.13562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867103/
https://www.ncbi.nlm.nih.gov/pubmed/29441715
http://dx.doi.org/10.1111/jcmm.13562

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