Elevated mitochondrial activity distinguishes fibrogenic hepatic stellate cells and sensitizes for selective inhibition by mitotropic doxorubicin

Activation of hepatic stellate cells (HSCs) is an integral component of the wound‐healing process in liver injury/inflammation. However, uncontrolled activation of HSCs leads to constant secretion of collagen‐rich extracellular matrix (ECM) proteins, resulting in liver fibrosis. The enhanced ECM syn...

Descripción completa

Detalles Bibliográficos
Autores principales: Gajendiran, Priya, Vega, Leonel Iglesias, Itoh, Kie, Sesaki, Hiromi, Vakili, Mohammad Reza, Lavasanifar, Afsaneh, Hong, Kelvin, Mezey, Esteban, Ganapathy‐Kanniappan, Shanmugasundaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867155/
https://www.ncbi.nlm.nih.gov/pubmed/29397578
http://dx.doi.org/10.1111/jcmm.13501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867155/
https://www.ncbi.nlm.nih.gov/pubmed/29397578
http://dx.doi.org/10.1111/jcmm.13501

Ejemplares similares