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Lipopolysaccharide enhances TGF‐β1 signalling pathway and rat pancreatic fibrosis

Pancreatic stellate cells (PSCs) play a critical role in fibrogenesis during alcoholic chronic pancreatitis (ACP). Transforming growth factor‐beta1 (TGF‐β1) is a key regulator of extracellular matrix production and PSC activation. Endotoxin lipopolysaccharide (LPS) has been recognized as a trigger f...

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Detalles Bibliográficos
Autores principales: Sun, Li, Xiu, Ming, Wang, Shuhua, Brigstock, David R., Li, Hongyan, Qu, Limei, Gao, Runping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867168/
https://www.ncbi.nlm.nih.gov/pubmed/29424488
http://dx.doi.org/10.1111/jcmm.13526