Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor

OBJECTIVES: Systemic sclerosis (SSc) is characterised by tissue fibrosis and vasculopathy with defective angiogenesis. Transforming growth factor beta (TGF-β) plays a major role in tissue fibrosis, including downregulation of caveolin-1 (Cav-1); however, its role in defective angiogenesis is less cl...

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Detalles Bibliográficos
Autores principales: Liakouli, Vasiliki, Elies, Jacobo, El-Sherbiny, Yasser Mohamed, Scarcia, Margherita, Grant, Gary, Abignano, Giuseppina, Derrett-Smith, Emma C, Esteves, Filomena, Cipriani, Paola, Emery, Paul, Denton, Christopher P, Giacomelli, Roberto, Mavria, Georgia, Del Galdo, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867407/
https://www.ncbi.nlm.nih.gov/pubmed/29259049
http://dx.doi.org/10.1136/annrheumdis-2017-212120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867407/
https://www.ncbi.nlm.nih.gov/pubmed/29259049
http://dx.doi.org/10.1136/annrheumdis-2017-212120

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