Computer-aided design of temozolomide derivatives based on alkylglycerone phosphate synthase structure with isothiocyanate and their pharmacokinetic/toxicity prediction and anti-tumor activity in vitro

Despite the development of temozolomide (TMZ), a novel type of glioma therapeutic drug, malignant glioma remains to cause severe damage to human health. The present study aimed to utilize the molecular biological differences between tumor and normal cells to design TMZ derivatives with improved sele...

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Detalles Bibliográficos
Autores principales: Yang, Bing, Li, Xiaobo, He, Lu, Zhu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867473/
https://www.ncbi.nlm.nih.gov/pubmed/29599977
http://dx.doi.org/10.3892/br.2018.1051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867473/
https://www.ncbi.nlm.nih.gov/pubmed/29599977
http://dx.doi.org/10.3892/br.2018.1051

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