p66(Shc) Inactivation Modifies RNS Production, Regulates Sirt3 Activity, and Improves Mitochondrial Homeostasis, Delaying the Aging Process in Mouse Brain

Programmed and damage aging theories have traditionally been conceived as stand-alone schools of thought. However, the p66(Shc) adaptor protein has demonstrated that aging-regulating genes and reactive oxygen species (ROS) are closely interconnected, since its absence modifies metabolic homeostasis...

Descripción completa

Detalles Bibliográficos
Autores principales: Pérez, Hernán, Finocchietto, Paola Vanesa, Alippe, Yael, Rebagliati, Inés, Elguero, María Eugenia, Villalba, Nerina, Poderoso, Juan José, Carreras, María Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867558/
https://www.ncbi.nlm.nih.gov/pubmed/29721150
http://dx.doi.org/10.1155/2018/8561892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867558/
https://www.ncbi.nlm.nih.gov/pubmed/29721150
http://dx.doi.org/10.1155/2018/8561892

Ejemplares similares