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p66(Shc) Inactivation Modifies RNS Production, Regulates Sirt3 Activity, and Improves Mitochondrial Homeostasis, Delaying the Aging Process in Mouse Brain

Programmed and damage aging theories have traditionally been conceived as stand-alone schools of thought. However, the p66(Shc) adaptor protein has demonstrated that aging-regulating genes and reactive oxygen species (ROS) are closely interconnected, since its absence modifies metabolic homeostasis...

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Detalles Bibliográficos
Autores principales:	Pérez, Hernán, Finocchietto, Paola Vanesa, Alippe, Yael, Rebagliati, Inés, Elguero, María Eugenia, Villalba, Nerina, Poderoso, Juan José, Carreras, María Cecilia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867558/ https://www.ncbi.nlm.nih.gov/pubmed/29721150 http://dx.doi.org/10.1155/2018/8561892

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