Tumor-Shed Antigen Affects Antibody Tumor Targeting: Comparison of Two (89)Zr-Labeled Antibodies Directed against Shed or Nonshed Antigens

We investigated the effect of shed antigen mesothelin on the tumor uptake of amatuximab, a therapeutic anti-mesothelin mAb clinically tested in mesothelioma patients. The B3 mAb targeting a nonshed antigen was also analyzed for comparison. The mouse model implanted with A431/H9 tumor, which expresse...

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Detalles Bibliográficos
Autores principales: Lee, Jae-Ho, Kim, Heejung, Yao, Zhengsheng, Szajek, Lawrence P., Grasso, Luigi, Kim, Insook, Paik, Chang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867561/
https://www.ncbi.nlm.nih.gov/pubmed/29720923
http://dx.doi.org/10.1155/2018/2461257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867561/
https://www.ncbi.nlm.nih.gov/pubmed/29720923
http://dx.doi.org/10.1155/2018/2461257

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