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Tumor-Shed Antigen Affects Antibody Tumor Targeting: Comparison of Two (89)Zr-Labeled Antibodies Directed against Shed or Nonshed Antigens

We investigated the effect of shed antigen mesothelin on the tumor uptake of amatuximab, a therapeutic anti-mesothelin mAb clinically tested in mesothelioma patients. The B3 mAb targeting a nonshed antigen was also analyzed for comparison. The mouse model implanted with A431/H9 tumor, which expresse...

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Detalles Bibliográficos
Autores principales:	Lee, Jae-Ho, Kim, Heejung, Yao, Zhengsheng, Szajek, Lawrence P., Grasso, Luigi, Kim, Insook, Paik, Chang H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867561/ https://www.ncbi.nlm.nih.gov/pubmed/29720923 http://dx.doi.org/10.1155/2018/2461257

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