Cargando…

Deep-Coverage MPS Analysis of Heteroplasmic Variants within the mtGenome Allows for Frequent Differentiation of Maternal Relatives

Distinguishing between maternal relatives through mitochondrial (mt) DNA sequence analysis has been a longstanding desire of the forensic community. Using a deep-coverage, massively parallel sequencing (DCMPS) approach, we studied the pattern of mtDNA heteroplasmy across the mtgenomes of 39 mother-c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holland, Mitchell M., Makova, Kateryna D., McElhoe, Jennifer A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867845/ https://www.ncbi.nlm.nih.gov/pubmed/29495418 http://dx.doi.org/10.3390/genes9030124

Ejemplares similares

Routine Mitogenome MPS Analysis from 1 and 5 mm of Rootless Human Hair
por: Canale, Lauren C., et al.
Publicado: (2022)

A Protocol for mtGenome Analysis on Large Sample Numbers
por: Hamoy, Igor G, et al.
Publicado: (2014)

Evaluation of next generation mtGenome sequencing using the Ion Torrent Personal Genome Machine (PGM)()
por: Parson, Walther, et al.
Publicado: (2013)

First mtgenome sequences from three genera and phylogenetic relationships of the family Apidae based on mtgenome sequences (Hymenoptera: Apoidea)
por: Wen, Zhong-Quan, et al.
Publicado: (2021)

Human Mitochondrial Control Region and mtGenome: Design and Forensic Validation of NGS Multiplexes, Sequencing and Analytical Software
por: Holt, Cydne L., et al.
Publicado: (2021)

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
por: Filograna, R., et al.
Publicado: (2019)

Detection of Heteroplasmic Mitochondrial DNA in Single Mitochondria
por: Reiner, Joseph E., et al.
Publicado: (2010)

A Naturally Heteroplasmic Clam Provides Clues about the Effects of Genetic Bottleneck on Paternal mtDNA
por: Iannello, Mariangela, et al.
Publicado: (2021)

Threshold of heteroplasmic truncating MT-ATP6 mutation in reprogramming, Notch hyperactivation and motor neuron metabolism
por: Kenvin, Sebastian, et al.
Publicado: (2021)

Elimination of Mutant mtDNA by an Optimized mpTALEN Restores Differentiation Capacities of Heteroplasmic MELAS-iPSCs
por: Yahata, Naoki, et al.
Publicado: (2020)

Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro
por: Pezet, Mikael G., et al.
Publicado: (2021)

Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness
por: Meshnik, Lana, et al.
Publicado: (2022)

Editor’s Note: A Naturally Heteroplasmic Clam Provides Clues about the Effects of Genetic Bottleneck on Paternal mtDNA
Publicado: (2021)

Ketogenic treatment reduces the percentage of a LHON heteroplasmic mutation and increases mtDNA amount of a LHON homoplasmic mutation
por: Emperador, Sonia, et al.
Publicado: (2019)

Reducing the Number of Mismatches between Hairs and Buccal References When Analysing mtDNA Heteroplasmic Variation by Massively Parallel Sequencing
por: van der Gaag, Kristiaan J., et al.
Publicado: (2020)

Second generation sequencing allows for mtDNA mixture deconvolution and high resolution detection of heteroplasmy
por: Holland, Mitchell M., et al.
Publicado: (2011)

Heteroplasmic mitochondrial DNA variants in cardiovascular diseases
por: Calabrese, Claudia, et al.
Publicado: (2022)

Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance
por: Arthur, Charles R, et al.
Publicado: (2009)

Heteroplasmic mitochondrial DNA mutations in normal and tumor cells
por: He, Yiping, et al.
Publicado: (2010)

Recent Advances in Detecting Mitochondrial DNA Heteroplasmic Variations
por: Duan, Mengqin, et al.
Publicado: (2018)

Heteroplasmic mitochondrial DNA mutations in frontotemporal lobar degeneration
por: Nie, Yu, et al.
Publicado: (2022)

Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A>G Cybrid Cells
por: Raap, Anton K., et al.
Publicado: (2012)

Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila
por: Kandul, Nikolay P., et al.
Publicado: (2016)

Heteroplasmic mitochondrial genomes of a Raillietina tapeworm in wild Pangolin
por: Tuli, Merga Daba, et al.
Publicado: (2022)

Organelle bottlenecks facilitate evolvability by traversing heteroplasmic fitness valleys
por: Radzvilavicius, Arunas L., et al.
Publicado: (2022)

Heteroplasmic Variants of Mitochondrial DNA in Atherosclerotic Lesions of Human Aortic Intima
por: Sobenin, Igor A., et al.
Publicado: (2019)

Plant organellar genomes utilize gene conversion to drive heteroplasmic sorting
por: Schaffner, Samantha H., et al.
Publicado: (2022)

Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer
por: Li, Yanni, et al.
Publicado: (2023)

Intraspecific and heteroplasmic variations, gene losses and inversions in the chloroplast genome of Astragalus membranaceus
por: Lei, Wanjun, et al.
Publicado: (2016)

The Detection and Partial Localisation of Heteroplasmic Mutations in the Mitochondrial Genome of Patients with Diabetic Retinopathy
por: Malik, Afshan N., et al.
Publicado: (2019)

Data on heteroplasmic mutations in mitochondrial genomes of loggerhead and hawksbill sea turtles: First approach
por: Delgado-Cano, David, et al.
Publicado: (2019)

Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality
por: Hong, Yun Soo, et al.
Publicado: (2023)

Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination
por: Mjelle, Kenneth A, et al.
Publicado: (2008)

A persistent mitochondrial deletion reduces fitness and sperm performance in heteroplasmic populations of C. elegans
por: Liau, Wei-Siang, et al.
Publicado: (2007)

Multiple Conserved Heteroplasmic Sites in tRNA Genes in the Mitochondrial Genomes of Terrestrial Isopods (Oniscidea)
por: Chandler, Christopher H., et al.
Publicado: (2015)

New Variant of MELAS Syndrome With Executive Dysfunction, Heteroplasmic Point Mutation in the MT-ND4 Gene (m.12015T>C; p.Leu419Pro) and Comorbid Polyglandular Autoimmune Syndrome Type 2
por: Endres, Dominique, et al.
Publicado: (2019)

Structure-Related Differences between Cytochrome Oxidase I Proteins in a Stable Heteroplasmic Mitochondrial System
por: Skibinski, David O F, et al.
Publicado: (2017)

Commentary: New Variant of MELAS Syndrome With Executive Dysfunction, Heteroplasmic Point Mutation in the MT-ND4 Gene (m.12015T>C; p.Leu419Pro) and Comorbid Polyglandular Autoimmune Syndrome Type 2
por: Finsterer, Josef
Publicado: (2019)

Maternal mosaicism for IDUA deletion clarifies recurrence risk in MPS I
por: Breen, Catherine, et al.
Publicado: (2016)

Coding region structural heterogeneity and turnover of transcription start sites contribute to divergence in expression between duplicate genes
por: Park, Chungoo, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_2o6h30bo275oh58gie8h3h5ntv