Cargando…

Resolving the Enigma of the Clonal Expansion of mtDNA Deletions

Mitochondria are cell organelles that are special since they contain their own genetic material in the form of mitochondrial DNA (mtDNA). Damage and mutations of mtDNA are not only involved in several inherited human diseases but are also widely thought to play an important role during aging. In bot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kowald, Axel, Kirkwood, Thomas B.L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867847/ https://www.ncbi.nlm.nih.gov/pubmed/29495484 http://dx.doi.org/10.3390/genes9030126

Ejemplares similares

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans
por: Baines, Holly L., et al.
Publicado: (2014)

Clonal expansion of mtDNA deletions: different disease models assessed by digital droplet PCR in single muscle cells
por: Trifunov, Selena, et al.
Publicado: (2018)

Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations
por: Tam, Zhi Yang, et al.
Publicado: (2015)

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations
por: Payne, Brendan A I, et al.
Publicado: (2011)

When man got his mtDNA deletions?
por: Popadin, Konstantin, et al.
Publicado: (2014)

Mitochondrial Ophthalmoplegia Is Not Only due to mtDNA Deletions
por: Finsterer, Josef
Publicado: (2019)

The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging
por: Edgar, Daniel, et al.
Publicado: (2009)

Wernicke–Korsakoff syndrome associated with mtDNA disease
por: Jimoh, Idris Janos, et al.
Publicado: (2020)

ALS spinal neurons show varied and reduced mtDNA gene copy numbers and increased mtDNA gene deletions
por: Keeney, Paula M, et al.
Publicado: (2010)

Sequence conservation of mitochondrial (mt)DNA during expansion of clonal mammary epithelial populations suggests a common mtDNA template in CzechII mice
por: Johnson, Jabril R., et al.
Publicado: (2020)

mtDNA Deletion in an Iranian Infant with Pearson Marrow Syndrome
por: Arzanian, Mohammad Taghi, et al.
Publicado: (2010)

Response to: ‘when man got his mtDNA deletions?’
por: Taylor, Sean D, et al.
Publicado: (2014)

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions
por: Rebelo, Adriana P., et al.
Publicado: (2009)

Harnessing mtDNA variation to resolve ambiguity in ‘Redfish’ sold in Europe
por: Shum, Peter, et al.
Publicado: (2017)

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
por: Suissa, Sarit, et al.
Publicado: (2009)

MELAS and Kearns–Sayre overlap syndrome due to the mtDNA m. A3243G mutation and large-scale mtDNA deletions
por: Yu, Nian, et al.
Publicado: (2016)

The Author Reply: Mitochondrial Ophthalmoplegia Is Not Only due to mtDNA Deletions
por: Lee, Young-Mock
Publicado: (2019)

mtDNA deletions responsible for unsuccessful pregnancy after in- vitro fertilization
Publicado: (2020)

Peripheral neuropathy in patients with CPEO associated with single and multiple mtDNA deletions
por: Lehmann, Diana, et al.
Publicado: (2016)

Where mtDNA is made
por: LeBrasseur, Nicole
Publicado: (2003)

Melanesian mtDNA Complexity
por: Friedlaender, Jonathan S., et al.
Publicado: (2007)

Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints
por: Dong, Dawei W, et al.
Publicado: (2014)

Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions
por: Fuke, Satoshi, et al.
Publicado: (2014)

Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus
por: Kasahara, T, et al.
Publicado: (2016)

Using urine to diagnose large‐scale mtDNA deletions in adult patients
por: Varhaug, Kristin N., et al.
Publicado: (2020)

Biallelic Variants in ENDOG Associated with Mitochondrial Myopathy and Multiple mtDNA Deletions
por: Nasca, Alessia, et al.
Publicado: (2022)

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
por: Filograna, R., et al.
Publicado: (2019)

Genomics versus mtDNA for resolving stock structure in the silky shark (Carcharhinus falciformis)
por: Kraft, Derek W., et al.
Publicado: (2020)

Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation
por: Stenberg, Simon, et al.
Publicado: (2022)

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease
por: Nicholls, Thomas J., et al.
Publicado: (2014)

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
por: van Tienen, Florence, et al.
Publicado: (2019)

MPV17 mutation causes neuropathy and leukoencephalopathy with multiple mtDNA deletions in muscle
por: Blakely, Emma L., et al.
Publicado: (2012)

Origins and Evolution of the Etruscans’ mtDNA
por: Ghirotto, Silvia, et al.
Publicado: (2013)

mtDNA in the Pathogenesis of Cardiovascular Diseases
por: Wang, Lili, et al.
Publicado: (2021)

Mitochondrial dysfunction and autism: comprehensive genetic analyses of children with autism and mtDNA deletion
por: Varga, Noémi Ágnes, et al.
Publicado: (2018)

Role of Direct Repeat and Stem-Loop Motifs in mtDNA Deletions: Cause or Coincidence?
por: Lakshmanan, Lakshmi Narayanan, et al.
Publicado: (2012)

Mutation Load of Single, Large-Scale Deletions of mtDNA in Mitotic and Postmitotic Tissues
por: Jeppesen, Tina D., et al.
Publicado: (2020)

Kearns‐Sayre syndrome case. Novel 5,9 kb mtDNA deletion
por: Grigalionienė, Kristina, et al.
Publicado: (2022)

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats
por: Chimienti, Guglielmina, et al.
Publicado: (2019)

Deep Rooting In-Situ Expansion of mtDNA Haplogroup R8 in South Asia
por: Thangaraj, Kumarasamy, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_npl8p39v1a0b232pqrff85gbcg