Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity

Tumor heterogeneity can be traced back to a small subset of cancer stem cells (CSCs), which can be derived from a single stem cell and show chemoresistance. Recent studies showed that CSCs are sensitive to mitochondrial targeting antibiotics such as doxycycline. However, little is known about how ca...

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Detalles Bibliográficos
Autores principales: Matsumoto, Takashi, Uchiumi, Takeshi, Monji, Keisuke, Yagi, Mikako, Setoyama, Daiki, Amamoto, Rie, Matsushima, Yuichi, Shiota, Masaki, Eto, Masatoshi, Kang, Dongchon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868058/
https://www.ncbi.nlm.nih.gov/pubmed/29184058
http://dx.doi.org/10.1038/s41389-017-0009-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868058/
https://www.ncbi.nlm.nih.gov/pubmed/29184058
http://dx.doi.org/10.1038/s41389-017-0009-3

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